Three people alive have ever faced all three in a lifetime, unless you want to count the Angel. Anyway, the three people? Sam and Dean Winchester, and Bobby Singer. Bobby has been gone for a long time because of the second monster listed, but Sammy and Dean seem to be getting along fine with the help of Castiel. Sam's gone full paranoia once or twice over being in Lucifer's cage for a while, but Cas soon switched the torture over to himself and took Sam's spot in the hospital. Dean's being the protective older brother as usual, but now he has more than one person to worry about, since Cas went and took the torture of having Lucifer screaming in his head at every moment of the day. Dean's always been protective, but since Sammy became a hunter again, he's been on edge a lot more, especially since they lost their dad, and now their adoptive dad. Bobby Singer was a friend of John Winchester, the boys' dad; and when John died, Bobby took over caring for the boys when needed. In my opinion Bobby was a good dad, and he held strong up until the moment he died.
